NAMPT activation uncovers a senescence-specific vulnerability and promotes healthy aging in combination with NAM

Senescent cells express elevated intracellular NAMPT, the rate-limiting enzyme in the NAD+ salvage pathway, making them metabolically distinct. The authors propose that activating NAMPT while providing NAM substrate can restore NAD+ homeostasis and simultaneously create a senescence-specific vulnerability. This dual strategy contrasts with approaches that only boost NAD+ or only clear senescent cells, potentially improving efficacy. As a preprint on bioRxiv, the findings require peer review and validation in mammalian models and human trials. If confirmed, this could inform combination therapies for age-related diseases and extend healthspan.