Randomized metformin and cognitive outcomes in the Diabetes Prevention Program Outcomes Study

The DPPOS is a long-term follow-up of the Diabetes Prevention Program, a randomized trial originally testing metformin and lifestyle intervention for diabetes prevention. This analysis specifically examines cognitive impairment syndromes and trajectories of cognitive test performance over time. The results are intended to clarify prior observations suggesting both protective and harmful associations between metformin and dementia. Findings could influence clinical decisions for millions using metformin and guide future dementia prevention strategies.