BAG6-RNF115 Couples Protein Quality Control with Ribosome Assembly

The authors used unbiased quantitative proteomics to uncover new interactors of the BAG6 complex, identifying RNF115 as a partner that couples protein quality control with ribosome assembly. This suggests that BAG6 surveils not only misfolded or mislocalized proteins but also participates in the biogenesis of ribosomes, a fundamental cellular process. The study provides a mechanistic link between ubiquitination pathways and translation, with potential implications for understanding diseases stemming from proteostasis or ribosomal defects. As a preprint, the findings require peer review, but they highlight a novel regulatory node that could be explored for therapeutic targeting in conditions like ribosomopathies or neurodegeneration.