A modular cranial window enabling maintainable widefield optical access in non-human primates

The PRIME (Primate Reconfigurable Interchangeable) cranial window is designed to address mechanical instability and progressive tissue responses that degrade optical clarity in chronic primate imaging. Unlike conventional fixed windows, this modular design allows for maintainable and reconfigurable cortical access, which is critical for large craniotomies in primates. The approach targets longitudinal studies that require stable yet flexible imaging over extended periods. This advance could enable more reliable tracking of neural dynamics in behaviorally trained primates, supporting research in systems neuroscience. The reconfigurability may also allow adjustments or interventions without repeated surgeries, reducing animal burden.