Talus Bio’s Structure-Free AI Model Targets Unstructured Proteins in Their Native Cellular Context

Intrinsically disordered proteins have resisted structure-based drug discovery because they lack a stable fold that can be modeled.

Talus Bio's structure-free AI model sidesteps that limitation by targeting these proteins in their native cellular environment instead of in isolation or from a predicted structure. The approach is aimed at a class of targets that conventional structure-based methods have struggled to address.