Longitudinal real-world treatment and hospitalisation dynamics in relation to genetic liability across primary psychotic disorders and bipolar disorder

The study analyzed data from the Estonian Biobank (N = 212,000) to investigate longitudinal associations between polygenic risk for primary psychotic disorders (PPD) and bipolar disorder (BD) and clinical outcomes in routine care. By linking biobank genetics with health records, the authors tracked treatment exposure and hospitalisation episodes over time. This real-world approach complements clinical trial evidence, which often underrepresents long-term effectiveness and heterogeneity. The findings highlight how genetic liability may inform prognosis and healthcare planning, though as a preprint the results have not yet undergone peer review.