Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids

Uterine fibroids are benign tumors characterized by excessive extracellular matrix deposition, abnormal vasculature, and tissue stiffening, but the cellular programs coordinating these features have been unclear. This study shows that cellular senescence in fibroids is not a uniform state but comprises functionally specialized cell identities that appear to link matrix remodeling with vascular alterations. By characterizing this heterogeneity, the findings could open new avenues for targeted therapies that address fibrosis and vascular abnormalities without surgery. The results are presented as a preprint on bioRxiv and have not yet undergone peer review, so further validation is needed.