Genetic Determinants of Chemotherapy-Induced Oral Mucositis in Children with Solid Malignancies

The MARVEL-PIC study at the Royal Children's Hospital enrolled 101 children with solid malignancies to examine genetic determinants of oral mucositis severity, a common and painful chemotherapy side effect. Unlike prior work centered on hematological cancers, this study targets solid tumors, potentially revealing distinct genetic associations. Understanding these variants could enable personalized prophylactic protocols, reducing treatment interruptions and improving quality of life. Further validation in larger cohorts is needed before clinical translation.