Change of prognostic nutritional index after three months of initial hemodialysis is a predictor of long-term outcomes for patients with uremia

The study focuses on maintenance hemodialysis (MHD) patients and tests the hypothesis that nutritional and immune status after a three-month stabilization period is a stronger prognostic indicator than initial values. Previous research has used Geriatric Nutritional Risk Index (GNRI) and PNI at dialysis initiation to assess prognosis, but early physical status can be unstable. By measuring PNI change over the first three months, the authors aim to provide a more reliable predictor of long-term outcomes for uremia patients. This could inform more personalized nutritional interventions and risk stratification in clinical practice.